Drug Repositioning Screen on a New Primary Cell Line Identifies Potent Therapeutics for Glioblastoma

Drug Repositioning Screen on a New Primary Cell Line Identifies Potent Therapeutics for Glioblastoma

Glioblastoma is a malignant brain cancer with limited treatment options and high mortality rate. While established glioblastoma cell line models provide valuable information, they ultimately lose most primary characteristics of tumors under long-term serum culture conditions. Therefore, established...

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Bibliographic Details
Main Authors: Filiz Senbabaoglu, Ali Cenk Aksu, Ahmet Cingoz, Fidan Seker-Polat, Esra Borklu-Yucel, İhsan Solaroglu, Tugba Bagci-Onder
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Neuroscience
Subjects:
glioblastoma
primary cell line
drug repurposing
Topotecan
Temozolomide
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.578316/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2020.578316/full

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