Microsatellite stable colorectal cancers stratified by the BRAF V600E mutation show distinct patterns of chromosomal instability.

Microsatellite stable colorectal cancers stratified by the BRAF V600E mutation show distinct patterns of chromosomal instability.

The BRAF (V600E) mutation in colorectal cancers that are microsatellite stable (MSS) confers a poor patient prognosis, whereas BRAF mutant microsatellite-unstable (MSI) colorectal cancers have an excellent prognosis. BRAF wild type cancers are typically MSS and display chromosomal instability (CIN)....

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Bibliographic Details
Main Authors: Catherine E Bond, Derek J Nancarrow, Leesa F Wockner, Leanne Wallace, Grant W Montgomery, Barbara A Leggett, Vicki L J Whitehall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3961279?pdf=render

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http://europepmc.org/articles/PMC3961279?pdf=render

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