Pericardial delta like non‐canonical NOTCH ligand 1 (Dlk1) augments fibrosis in the heart through epithelial to mesenchymal transition

Pericardial delta like non‐canonical NOTCH ligand 1 (Dlk1) augments fibrosis in the heart through epithelial to mesenchymal transition

Abstract Background Heart failure due to myocardial infarction (MI) involves fibrosis driven by epicardium‐derived cells (EPDCs) and cardiac fibroblasts, but strategies to inhibit and provide cardio‐protection remains poor. The imprinted gene, non‐canonical NOTCH ligand 1 (Dlk1), has previously been...

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Bibliographic Details
Main Authors: Charlotte Harken Jensen, Rikke Helin Johnsen, Tilde Eskildsen, Christina Baun, Ditte Gry Ellman, Shu Fang, Sara Thornby Bak, Svend Hvidsten, Lars Allan Larsen, Ann Mari Rosager, Lars Peter Riber, Mikael Schneider, Jo De Mey, Mads Thomassen, Mark Burton, Shizuka Uchida, Jorge Laborda, Ditte Caroline Andersen
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Clinical and Translational Medicine
Subjects:
cardiac fibrosis
Delta like non‐canonical NOTCH ligand 1 (Dlk1)
epicardium‐derived cells (EPDCs)
epithelial to mesenchymal transition
myocardial infarction
myocardial remodelling
Online Access:https://doi.org/10.1002/ctm2.1565

Internet

https://doi.org/10.1002/ctm2.1565

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