Quantitative muscle MRI captures early muscle degeneration in calpainopathy
Abstract To evaluate differences in qMRI parameters of muscle diffusion tensor imaging (mDTI), fat-fraction (FF) and water T2 time in leg muscles of calpainopathy patients (LGMD R1/D4) compared to healthy controls, to correlate those findings to clinical parameters and to evaluate if qMRI parameters...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23972-6 |
| _version_ | 1831891217324965888 |
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| author | Johannes Forsting Marlena Rohm Martijn Froeling Anne-Katrin Güttsches Nicolina Südkamp Andreas Roos Matthias Vorgerd Lara Schlaffke Robert Rehmann |
| author_facet | Johannes Forsting Marlena Rohm Martijn Froeling Anne-Katrin Güttsches Nicolina Südkamp Andreas Roos Matthias Vorgerd Lara Schlaffke Robert Rehmann |
| author_sort | Johannes Forsting |
| collection | DOAJ |
| description | Abstract To evaluate differences in qMRI parameters of muscle diffusion tensor imaging (mDTI), fat-fraction (FF) and water T2 time in leg muscles of calpainopathy patients (LGMD R1/D4) compared to healthy controls, to correlate those findings to clinical parameters and to evaluate if qMRI parameters show muscle degeneration in not-yet fatty infiltrated muscles. We evaluated eight thigh and seven calf muscles of 19 calpainopathy patients and 19 healthy matched controls. MRI scans were performed on a 3T MRI including a mDTI, T2 mapping and mDixonquant sequence. Clinical assessment was done with manual muscle testing, patient questionnaires (ACTIVLIM, NSS) as well as gait analysis. Average FF was significantly different in all muscles compared to controls (p < 0.001). In muscles with less than 8% FF a significant increase of FA (p < 0.005) and decrease of RD (p < 0.004) was found in high-risk muscles of calpainopathy patients. Water T2 times were increased within the low- and intermediate-risk muscles (p ≤ 0.045) but not in high-risk muscles (p = 0.062). Clinical assessments correlated significantly with qMRI values: QMFM vs. FF: r = − 0.881, p < 0.001; QMFM versus FA: r = − 0.747, p < 0.001; QMFM versus MD: r = 0.942, p < 0.001. A good correlation of FF and diffusion metrics to clinical assessments was found. Diffusion metrics and T2 values are promising candidates to serve as sensitive early and non-invasive methods to capture early muscle degeneration in non-fat-infiltrated muscles in calpainopathies. |
| first_indexed | 2024-04-11T06:54:42Z |
| format | Article |
| id | doaj.art-815aa00d380b4a2f959745644e150855 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2025-03-22T01:03:00Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-815aa00d380b4a2f959745644e1508552024-05-12T11:20:53ZengNature PortfolioScientific Reports2045-23222022-11-0112111010.1038/s41598-022-23972-6Quantitative muscle MRI captures early muscle degeneration in calpainopathyJohannes Forsting0Marlena Rohm1Martijn Froeling2Anne-Katrin Güttsches3Nicolina Südkamp4Andreas Roos5Matthias Vorgerd6Lara Schlaffke7Robert Rehmann8Department of Neurology, BG-University Hospital Bergmannsheil, Ruhr-University BochumDepartment of Neurology, BG-University Hospital Bergmannsheil, Ruhr-University BochumDepartment of Radiology, University Medical Centre UtrechtDepartment of Neurology, BG-University Hospital Bergmannsheil, Ruhr-University BochumDepartment of Neurology, BG-University Hospital Bergmannsheil, Ruhr-University BochumDepartment of Neurology, BG-University Hospital Bergmannsheil, Ruhr-University BochumDepartment of Neurology, BG-University Hospital Bergmannsheil, Ruhr-University BochumDepartment of Neurology, BG-University Hospital Bergmannsheil, Ruhr-University BochumDepartment of Neurology, BG-University Hospital Bergmannsheil, Ruhr-University BochumAbstract To evaluate differences in qMRI parameters of muscle diffusion tensor imaging (mDTI), fat-fraction (FF) and water T2 time in leg muscles of calpainopathy patients (LGMD R1/D4) compared to healthy controls, to correlate those findings to clinical parameters and to evaluate if qMRI parameters show muscle degeneration in not-yet fatty infiltrated muscles. We evaluated eight thigh and seven calf muscles of 19 calpainopathy patients and 19 healthy matched controls. MRI scans were performed on a 3T MRI including a mDTI, T2 mapping and mDixonquant sequence. Clinical assessment was done with manual muscle testing, patient questionnaires (ACTIVLIM, NSS) as well as gait analysis. Average FF was significantly different in all muscles compared to controls (p < 0.001). In muscles with less than 8% FF a significant increase of FA (p < 0.005) and decrease of RD (p < 0.004) was found in high-risk muscles of calpainopathy patients. Water T2 times were increased within the low- and intermediate-risk muscles (p ≤ 0.045) but not in high-risk muscles (p = 0.062). Clinical assessments correlated significantly with qMRI values: QMFM vs. FF: r = − 0.881, p < 0.001; QMFM versus FA: r = − 0.747, p < 0.001; QMFM versus MD: r = 0.942, p < 0.001. A good correlation of FF and diffusion metrics to clinical assessments was found. Diffusion metrics and T2 values are promising candidates to serve as sensitive early and non-invasive methods to capture early muscle degeneration in non-fat-infiltrated muscles in calpainopathies.https://doi.org/10.1038/s41598-022-23972-6 |
| spellingShingle | Johannes Forsting Marlena Rohm Martijn Froeling Anne-Katrin Güttsches Nicolina Südkamp Andreas Roos Matthias Vorgerd Lara Schlaffke Robert Rehmann Quantitative muscle MRI captures early muscle degeneration in calpainopathy Scientific Reports |
| title | Quantitative muscle MRI captures early muscle degeneration in calpainopathy |
| title_full | Quantitative muscle MRI captures early muscle degeneration in calpainopathy |
| title_fullStr | Quantitative muscle MRI captures early muscle degeneration in calpainopathy |
| title_full_unstemmed | Quantitative muscle MRI captures early muscle degeneration in calpainopathy |
| title_short | Quantitative muscle MRI captures early muscle degeneration in calpainopathy |
| title_sort | quantitative muscle mri captures early muscle degeneration in calpainopathy |
| url | https://doi.org/10.1038/s41598-022-23972-6 |
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