Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs

Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs

Abstract Background Accumulating evidence suggests that epigenetic changes play key roles in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the dynamic regulation of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in diabetic peripheral blood DNA remains to be elucidated. Re...

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Bibliographic Details
Main Authors: Er-Feng Yuan, Ying Yang, Lin Cheng, Xujing Deng, Shao-Min Chen, Xin Zhou, Song-Mei Liu
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Clinical Epigenetics
Subjects:
5-methylcytosine
5-hydroxymethylcytosine
TET
SIRT6
Type 2 diabetes mellitus
Online Access:http://link.springer.com/article/10.1186/s13148-019-0660-y

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http://link.springer.com/article/10.1186/s13148-019-0660-y

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