Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer

Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer

Kuang He, Wen-Juan Gan Department of Pathology, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Wen-Juan Gan, Department of Pathology, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, Jiangsu, 215124, People’s Republic of...

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Những tác giả chính: He K, Gan WJ
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Dove Medical Press 2023-05-01
Loạt:Cancer Management and Research
Những chủ đề:
wnt pathway
colorectal carcinogenesis
apc
crc therapy
Truy cập trực tuyến:https://www.dovepress.com/wnt-catenin-signaling-pathway-in-the-development-and-progression-of-co-peer-reviewed-fulltext-article-CMAR
Miêu tả
Tóm tắt:Kuang He, Wen-Juan Gan Department of Pathology, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Wen-Juan Gan, Department of Pathology, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, Jiangsu, 215124, People’s Republic of China, Tel +86 0512-65955080, Email ganwenjuan@suda.edu.cnAbstract: The Wnt/β-catenin signaling pathway is a growth control pathway involved in various biological processes as well as the development and progression of cancer. Colorectal cancer (CRC) is one of the most common malignancies in the world. The hyperactivation of Wnt signaling is observed in almost all CRC and plays a crucial role in cancer-related processes such as cancer stem cell (CSC) propagation, angiogenesis, epithelial-mesenchymal transition (EMT), chemoresistance, and metastasis. This review will discuss how the Wnt/β-catenin signaling pathway is involved in the carcinogenesis and progression of CRC and related therapeutic approaches.Keywords: Wnt pathway, colorectal carcinogenesis, APC, CRC therapy
số ISSN:1179-1322

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