Monolayer culture alters EGFR inhibitor response through abrogation of microRNA-mediated feedback regulation

Monolayer culture alters EGFR inhibitor response through abrogation of microRNA-mediated feedback regulation

Abstract Ex vivo drug screening is a potentially powerful tool for the future of cancer care, but the accuracy of results is contingent on the culture model. Both monolayer (2D) and spheroid (3D) culture systems offer advantages, but given the differences in mechanical environment, we hypothesized t...

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Bibliographic Details
Main Authors: Angela Florio, Sarah Johnson, Rebecca Salvatori, George Vasmatzis
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Personalized medicine
Ex vivo drug screen
miR-146a
EGFR regulation
Lung adenocarcinoma
Patient-derived spheroids
Online Access:https://doi.org/10.1038/s41598-024-56920-7

Internet

https://doi.org/10.1038/s41598-024-56920-7

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