The Histone Demethylase HR Suppresses Breast Cancer Development through Enhanced CELF2 Tumor Suppressor Activity

The Histone Demethylase HR Suppresses Breast Cancer Development through Enhanced CELF2 Tumor Suppressor Activity

The <i>hairless</i> (<i>HR</i>) gene encodes a transcription factor with histone demethylase activity that is essential for development and tissue homeostasis. Previous studies suggest that mutational inactivation of HR promotes tumorigenesis. To investigate HR mutations in b...

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Bibliographic Details
Main Authors: Yao Shen, Jasvinder Singh, Bindeshwar Sah, Zhongming Chen, Wootae Ha, Christine Henzler, Tao Su, Lillian Xie, Yibin Deng, Gen Li, Hua Guo, Hanina Hibshoosh, Liang Liu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
hairless
breast cancer
histone methylation
CELF2
epigenetic therapy
Online Access:https://www.mdpi.com/2072-6694/14/19/4648

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https://www.mdpi.com/2072-6694/14/19/4648

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