The Histone Demethylase HR Suppresses Breast Cancer Development through Enhanced CELF2 Tumor Suppressor Activity

The Histone Demethylase HR Suppresses Breast Cancer Development through Enhanced CELF2 Tumor Suppressor Activity

The <i>hairless</i> (<i>HR</i>) gene encodes a transcription factor with histone demethylase activity that is essential for development and tissue homeostasis. Previous studies suggest that mutational inactivation of HR promotes tumorigenesis. To investigate HR mutations in b...

Full description

Bibliographic Details
Main Authors: Yao Shen, Jasvinder Singh, Bindeshwar Sah, Zhongming Chen, Wootae Ha, Christine Henzler, Tao Su, Lillian Xie, Yibin Deng, Gen Li, Hua Guo, Hanina Hibshoosh, Liang Liu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
hairless
breast cancer
histone methylation
CELF2
epigenetic therapy
Online Access:https://www.mdpi.com/2072-6694/14/19/4648

Similar Items

Similar Items