Rhubarb Protect Against Tubulointerstitial Fibrosis by Inhibiting TGF-β/Smad Pathway and Improving Abnormal Metabolome in Chronic Kidney Disease

Rhubarb Protect Against Tubulointerstitial Fibrosis by Inhibiting TGF-β/Smad Pathway and Improving Abnormal Metabolome in Chronic Kidney Disease

Tubulointerstitial fibrosis is the final common pathway for all kidney diseases leading to chronic kidney disease (CKD). TGF-β/Smad signaling pathway plays a key role in renal fibrosis. Previous studies have revealed that rhubarb extracts attenuated the increase of transforming growth factor-β 1 (TG...

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Bibliographic Details
Main Authors: Zhi-Hao Zhang, Ming-Hua Li, Dan Liu, Hua Chen, Dan-Qian Chen, Ning-Hua Tan, Shuang-Cheng Ma, Ying-Yong Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
chronic kidney disease
rhubarb
TGF-β/Smad signaling
metabolomics
tubulointerstitial fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01029/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.01029/full

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