PM2.5 exposure triggers cell death through lysosomal membrane permeabilization and leads to ferroptosis insensitivity via the autophagy dysfunction/p62-KEAP1-NRF2 activation in neuronal cells

PM2.5 exposure triggers cell death through lysosomal membrane permeabilization and leads to ferroptosis insensitivity via the autophagy dysfunction/p62-KEAP1-NRF2 activation in neuronal cells

PM2.5 exposure can be associated with the onset of neurodegenerative diseases, with oxidative stress-induced cellular homeostasis disruption and cell death as one of the main mechanisms. However, the exact cellular and molecular processes are still rarely investigated. Autophagy and KEAP1-NRF2 (Kelc...

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Bibliographic Details
Main Authors: Min Wei, Guangming Bao, Song Li, Zhaofei Yang, Cheng Cheng, Weidong Le
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Ambient fine particulate matter (PM2.5)
Autophagic-lysosomal dysfunction
Lysosomal membrane permeabilization (LMP)
P62-keap1-Nrf2 signaling pathway
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322011733

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http://www.sciencedirect.com/science/article/pii/S0147651322011733

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