Knowledge-guided gene prioritization reveals new insights into the mechanisms of chemoresistance

Knowledge-guided gene prioritization reveals new insights into the mechanisms of chemoresistance

Abstract Background Identification of genes whose basal mRNA expression predicts the sensitivity of tumor cells to cytotoxic treatments can play an important role in individualized cancer medicine. It enables detailed characterization of the mechanism of action of drugs. Furthermore, screening the e...

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Bibliographic Details
Main Authors: Amin Emad, Junmei Cairns, Krishna R. Kalari, Liewei Wang, Saurabh Sinha
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Genome Biology
Subjects:
Chemoresistance
Chemotherapy
Drug sensitivity
Gene interaction network
Gene prioritization
Network-based algorithm
Online Access:http://link.springer.com/article/10.1186/s13059-017-1282-3

Internet

http://link.springer.com/article/10.1186/s13059-017-1282-3

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