Inducible caspase-9 suicide gene under control of endogenous oct4 to safeguard mouse and human pluripotent stem cell therapy

Inducible caspase-9 suicide gene under control of endogenous oct4 to safeguard mouse and human pluripotent stem cell therapy

Pluripotent stem cells (PSCs) are promising in regenerative medicine. A major challenge of PSC therapy is the risk of teratoma formation because of the contamination of undifferentiated stem cells. Constitutive promoters or endogenous SOX2 promoters have been used to drive inducible caspase-9 (iCasp...

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Bibliographic Details
Main Authors: Yang Liu, Yang Yang, Yangyang Suo, Chuan Li, Min Chen, Shuwen Zheng, Hao Li, Chengcheng Tang, Nana Fan, Ting Lan, Jizeng Zhou, Yingying Li, Jiaowei Wang, Huangyao Chen, Qingjian Zou, Liangxue Lai
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
pluripotent stem cells (PSCs)
inducible caspase-9 (iCasp9) gene
apoptosis
OCT4 gene
teratoma formation
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122000158

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http://www.sciencedirect.com/science/article/pii/S2329050122000158

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