LONP1 Regulates Mitochondrial Accumulations of HMGB1 and Caspase-3 in CA1 and PV Neurons Following Status Epilepticus

LONP1 Regulates Mitochondrial Accumulations of HMGB1 and Caspase-3 in CA1 and PV Neurons Following Status Epilepticus

Lon protease 1 (LONP1) is a highly conserved serine peptidase that plays an important role in the protein quality control system in mammalian mitochondria. LONP1 catalyzes the degradation of oxidized, dysfunctional, and misfolded matrix proteins inside mitochondria and regulates mitochondrial gene e...

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Bibliographic Details
Main Authors: Ji-Eun Kim, Hana Park, Tae-Hyun Kim, Tae-Cheon Kang
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
caspase-3
epilepsy
HMGB1
LONP1
mitochondrial dynamics
Online Access:https://www.mdpi.com/1422-0067/22/5/2275

Internet

https://www.mdpi.com/1422-0067/22/5/2275

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