Potent neutralization of botulinum neurotoxin/B by synergistic action of antibodies recognizing protein and ganglioside receptor binding domain.

Potent neutralization of botulinum neurotoxin/B by synergistic action of antibodies recognizing protein and ganglioside receptor binding domain.

BACKGROUND: Botulinum neurotoxins (BoNTs), the causative agents for life-threatening human disease botulism, have been recognized as biological warfare agents. Monoclonal antibody (mAb) therapeutics hold considerable promise as BoNT therapeutics, but the potencies of mAbs against BoNTs are usually l...

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Bibliographic Details
Main Authors: Changchun Chen, Shuhui Wang, Huajing Wang, Xiaoyan Mao, Tiancheng Zhang, Guanghui Ji, Xin Shi, Tian Xia, Weijia Lu, Dapeng Zhang, Jianxin Dai, Yajun Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3430616?pdf=render

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http://europepmc.org/articles/PMC3430616?pdf=render

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