Hepatic myofibroblasts exert immunosuppressive effects independent of the immune checkpoint regulator PD-L1 in liver metastasis of pancreatic ductal adenocarcinoma

Hepatic myofibroblasts exert immunosuppressive effects independent of the immune checkpoint regulator PD-L1 in liver metastasis of pancreatic ductal adenocarcinoma

IntroductionPancreatic ductal adenocarcinoma (PDAC) represents the 4th most common cause of cancer-related deaths in Western countries. Most patients are diagnosed at advanced stages, often already with metastases. The main site of metastasis is the liver and hepatic myofibroblasts (HMF) play a pivo...

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Bibliographic Details
Main Authors: Silje Beckinger, Tina Daunke, Leon Aldag, Sandra Krüger, Steffen Heckl, Daniela Wesch, Heiner Schäfer, Christoph Röcken, Sascha Rahn, Susanne Sebens
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
immune evasion
3D coculture
hepatic metastasis
programmed death ligand 1
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1160824/full

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