Gut microbiota-derived cholic acid mediates neonatal brain immaturity and white matter injury under chronic hypoxia

Gut microbiota-derived cholic acid mediates neonatal brain immaturity and white matter injury under chronic hypoxia

Summary: Chronic hypoxia, common in neonates, disrupts gut microbiota balance, which is crucial for brain development. This study utilized cyanotic congenital heart disease (CCHD) patients and a neonatal hypoxic rat model to explore the association. Both hypoxic rats and CCHD infants exhibited brain...

Full description

Bibliographic Details
Main Authors: Yichen Yan, Xiaoli Zheng, Gang Liu, Guocheng Shi, Cong Li, Hongtong Chen, Xiaomin He, Kana Lin, Zhaohui Deng, Hao Zhang, Wei-Guang Li, Huiwen Chen, Xiaoping Tong, Zhongqun Zhu
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:iScience
Subjects:
Microbiome
Molecular biology
Neuroscience
Physiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224008551

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224008551

Similar Items