Clinical Staphylococcus aureus inhibits human T-cell activity through interaction with the PD-1 receptor

Clinical Staphylococcus aureus inhibits human T-cell activity through interaction with the PD-1 receptor

ABSTRACT Staphylococcus aureus (S. aureus) represents a major clinical challenge due to its explicit capacity to select mutations that increase antibiotic resistance and immune evasion. However, the molecular mechanisms are poorly defined, especially for adaptive immunity. Cancer immunotherapy targe...

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Bibliographic Details
Main Authors: Maiken Mellergaard, Sarah Line Skovbakke, Stine Dam Jepsen, Nafsika Panagiotopoulou, Amalie Bøge Rud Hansen, Weihua Tian, Astrid Lund, Rikke Illum Høgh, Sofie Hedlund Møller, Romain Guérillot, Ashleigh S. Hayes, Lise Tornvig Erikstrup, Lars Andresen, Anton Y. Peleg, Anders Rhod Larsen, Timothy P. Stinear, Aase Handberg, Christian Erikstrup, Benjamin P. Howden, Steffen Goletz, Dorte Frees, Søren Skov
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
clinical Staphylococcus aureus
immune evasion
adaptive immunity
ClpP mutation
T cells
Online Access:https://journals.asm.org/doi/10.1128/mbio.01349-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01349-23

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