Laquinimod Modulates Human Astrocyte Function and Dampens Astrocyte-Induced Neurotoxicity during Inflammation

Laquinimod Modulates Human Astrocyte Function and Dampens Astrocyte-Induced Neurotoxicity during Inflammation

Astrocytes greatly participate to inflammatory and neurotoxic reactions occurring in neurodegenerative diseases and are valuable pharmacological targets to support neuroprotection. Here we used human astrocytes generated from reprogrammed fibroblasts as a cellular model to study the effect of the co...

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Bibliographic Details
Main Authors: Emanuela Colombo, Rosaria Pascente, Daniela Triolo, Claudia Bassani, Anthea De Angelis, Francesca Ruffini, Linda Ottoboni, Giancarlo Comi, Gianvito Martino, Cinthia Farina
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
AHR
astrocytes
glutamate transporters
laquinimod
neurodegeneration
NFκB
Online Access:https://www.mdpi.com/1420-3049/25/22/5403

Internet

https://www.mdpi.com/1420-3049/25/22/5403

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