Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

Autosomal-dominant Schnyder corneal dystrophy (SCD) is characterized by corneal opacification owing to overaccumulation of cholesterol. SCD is caused by mutations in UBIAD1, which utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K2. Using cultured cells, we previously showed that s...

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Bibliographic Details
Main Authors: Youngah Jo, Jason S Hamilton, Seonghwan Hwang, Kristina Garland, Gennipher A Smith, Shan Su, Iris Fuentes, Sudha Neelam, Bonne M Thompson, Jeffrey G McDonald, Russell A DeBose-Boyd
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
ER-associated degradation
vitamin K
geranylgeranyl pyrophosphate
cholesterol
isoprenoid
Schnyder corneal dystrophy
Online Access:https://elifesciences.org/articles/44396

Internet

https://elifesciences.org/articles/44396

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