A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors

A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors

While human leukocyte antigen (HLA) and HLA-like proteins comprise an overwhelming majority of known ligands for NK-cell receptors, the interactions of NK-cell receptors with non-conventional ligands, particularly carbohydrate antigens, is less well described. We previously found through a bead-base...

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Bibliographic Details
Main Authors: Klara Klein, Angelique Hölzemer, Tim Wang, Tae-Eun Kim, Haley L. Dugan, Stephanie Jost, Marcus Altfeld, Wilfredo F. Garcia-Beltran
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
CRISPR
screen
KIR
heparan sulfate
NK cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.798235/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.798235/full

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