Cell softness renders cytotoxic T lymphocytes and T leukemic cells resistant to perforin-mediated killing

Cell softness renders cytotoxic T lymphocytes and T leukemic cells resistant to perforin-mediated killing

Abstract Mechanical force contributes to perforin pore formation at immune synapses, thus facilitating the cytotoxic T lymphocytes (CTL)-mediated killing of tumor cells in a unidirectional fashion. How such mechanical cues affect CTL evasion of perforin-mediated autolysis remains unclear. Here we sh...

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Bibliographic Details
Main Authors: Yabo Zhou, Dianheng Wang, Li Zhou, Nannan Zhou, Zhenfeng Wang, Jie Chen, Ruiyang Pang, Haixia Fu, Qiusha Huang, Fang Dong, Hui Cheng, Huafeng Zhang, Ke Tang, Jingwei Ma, Jiadi Lv, Tao Cheng, Roland Fiskesund, Xiaohui Zhang, Bo Huang
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45750-w

Internet

https://doi.org/10.1038/s41467-024-45750-w

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