miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

Abstract Locally advanced non-small cell lung cancer (NSCLC) is frequent at diagnosis and requires multimodal treatment approaches. Neoadjuvant chemotherapy (NACT) followed by surgery is the treatment of choice for operable locally advanced NSCLC (Stage IIIA). However, the majority of patients are N...

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Main Authors: Roberto Cuttano, Tommaso Colangelo, Juliana Guarize, Elisa Dama, Maria Pia Cocomazzi, Francesco Mazzarelli, Valentina Melocchi, Orazio Palumbo, Elena Marino, Elena Belloni, Francesca Montani, Manuela Vecchi, Massimo Barberis, Paolo Graziano, Andrea Pasquier, Julian Sanz-Ortega, Luis M. Montuenga, Cristiano Carbonelli, Lorenzo Spaggiari, Fabrizio Bianchi
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Hematology & Oncology
Subjects:
Lung cancer
NSCLC
microRNA
Gene expression
Chemotherapy
PD-L1
Online Access:https://doi.org/10.1186/s13045-022-01394-1

Internet

https://doi.org/10.1186/s13045-022-01394-1

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