Polylactide Conjugates of Camptothecin with Different Drug Release Abilities

Polylactide Conjugates of Camptothecin with Different Drug Release Abilities

Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (Pm = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitr...

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Bibliographic Details
Main Authors: Ewa Oledzka, Paweł Horeglad, Zuzanna Gruszczyńska, Andrzej Plichta, Grzegorz Nałęcz-Jawecki, Marcin Sobczak
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
macromolecular conjugates
biodegradable polymers
camptothecin
drug delivery systems
controlled release
Online Access:http://www.mdpi.com/1420-3049/19/12/19460

Internet

http://www.mdpi.com/1420-3049/19/12/19460

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