An integrative approach using real-world data to identify alternative therapeutic uses of existing drugs.

Different computational approaches are employed to efficiently identify novel repositioning possibilities utilizing different sources of information and algorithms. It is critical to propose high-valued candidate-repositioning possibilities before conducting lengthy in vivo validation studies that c...

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Bibliographic Details
Main Authors: Kouichi Hosomi, Mai Fujimoto, Kazutaka Ushio, Lili Mao, Juran Kato, Mitsutaka Takada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6177143?pdf=render