Enhanced self-renewal of human pluripotent stem cells by simulated microgravity

Abstract A systematic study on the biological effects of simulated microgravity (sµg) on human pluripotent stem cells (hPSC) is still lacking. Here, we used a fast-rotating 2-D clinostat to investigate the sµg effect on proliferation, self-renewal, and cell cycle regulation of hPSCs. We observed sig...

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Bibliographic Details
Main Authors: S. Timilsina, T. Kirsch-Mangu, S. Werth, B. Shepard, T. Ma, L. G. Villa-Diaz
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:npj Microgravity
Online Access:https://doi.org/10.1038/s41526-022-00209-4