H-Ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

H-Ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

Hemolysis, oxidative stress, inflammation, vaso-occlusion and organ infarction are hallmarks of sickle cell disease (SCD). We have previously shown that increases in heme oxygenase-1 (HO-1) activity detoxify heme and inhibit vaso-occlusion in transgenic mouse models of SCD. HO-1 releases Fe2+ from h...

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Bibliographic Details
Main Authors: Gregory M Vercellotti, Fatima B Khan, Heather eBechtel, Karl A Nath, Julia eNguyen, Chunseng eChen, Carol M Bruzzone, Graham eBrown, Clifford John Steer, Robert P Hebbel, John D. Belcher
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Pharmacology
Subjects:
Endothelium
Inflammation
Sickle Cell Disease
H-ferritin
vaso-occlusion
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00079/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00079/full

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