A Non-Nucleotide STING Agonist MSA-2 Synergized with Manganese in Enhancing STING Activation to Elicit Potent Anti-RNA Virus Activity in the Cells

A Non-Nucleotide STING Agonist MSA-2 Synergized with Manganese in Enhancing STING Activation to Elicit Potent Anti-RNA Virus Activity in the Cells

Both Manganese (Mn<sup>2+</sup>) and MSA-2 can activate the downstream signal pathway through stimulator of interferon genes (STING) and induce the expression of type I interferon, which is important for hosts to protect against DNA viruses. However, its effect on RNA viruses remains unk...

Full description

Bibliographic Details
Main Authors: Hanrui Lin, Rui Zhang, Hanyi Xiang, Xinqian Lin, Xiongting Huang, Jingsong Chen, Long Zhou, Zhidong Zhang, Yanmin Li
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Viruses
Subjects:
MSA-2
manganese
stimulator of interferon genes
Seneca Valley virus
antiviral effect
Online Access:https://www.mdpi.com/1999-4915/15/11/2138

Internet

https://www.mdpi.com/1999-4915/15/11/2138

Similar Items