Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages

Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages

Abstract Background Myelin that surrounds axons breaks in trauma and disease; e.g., peripheral nerve and spinal cord injuries (PNI and SCI) and multiple sclerosis (MS). Resulting myelin debris hinders repair if not effectively scavenged by Schwann cells and macrophages in PNI and by microglia in SCI...

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Bibliographic Details
Main Authors: Miri Gitik, Gerard Elberg, Fanny Reichert, Michael Tal, Shlomo Rotshenker
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Neuroinflammation
Subjects:
CD47
SIRPα
Nerve injury
Wallerian degeneration
Macrophages
Microglia
Online Access:https://doi.org/10.1186/s12974-023-02929-0

Internet

https://doi.org/10.1186/s12974-023-02929-0

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