Prolonged culturing of colonic epithelial organoids derived from healthy individuals and ulcerative colitis patients results in the decrease of LINE-1 methylation level

Prolonged culturing of colonic epithelial organoids derived from healthy individuals and ulcerative colitis patients results in the decrease of LINE-1 methylation level

Abstract Patient-derived human intestinal organoids are becoming an indispensable tool for the research of digestive system in health and disease. However, very little is still known about the long-term culturing effect on global genomic methylation level in colonic epithelial organoids derived from...

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Bibliographic Details
Main Authors: Ruta Inciuraite, Ruta Steponaitiene, Odeta Raudze, Ugne Kulokiene, Vytautas Kiudelis, Rokas Lukosevicius, Rasa Ugenskiene, Kestutis Adamonis, Gediminas Kiudelis, Laimas Virginijus Jonaitis, Juozas Kupcinskas, Jurgita Skieceviciene
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-55076-8

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https://doi.org/10.1038/s41598-024-55076-8

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