RUNX2 promotes gastric cancer progression through the transcriptional activation of MGAT5 and MMP13

IntroductionRUNX2 is overexpressed in gastric cancer but the mechanism(s) through which it promotes tumor progression remain undefined. Here, we investigated the role of RUNX2 on gastric cancer pathogenesis at the molecular level.MethodsThe qRT-PCR and western bolt were utilized to examine the mRNA...

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Bibliographic Details
Main Authors: Ying Wang, Zhibo Tan, Xiaoyu Li, Lili Zhang, Xiaojuan Pei
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1133476/full