Quantitative Analysis of the Cytoskeleton’s Role in Inward Rectifier KIR2.1 Forward and Backward Trafficking

Quantitative Analysis of the Cytoskeleton’s Role in Inward Rectifier KIR2.1 Forward and Backward Trafficking

Alteration of the inward rectifier current IK1, carried by KIR2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias. Congenital and acquired KIR2.1 malfunction frequently associates with aberrant ion channel trafficking. Cellular...

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Bibliographic Details
Main Authors: Encan Li, Vera Loen, Willem B. van Ham, Willy Kool, Marcel A. G. van der Heyden, Hiroki Takanari
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Physiology
Subjects:
ion channel
trafficking
cytoskeleton
Chloroquine
Nocodazole
Cytochalasin
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.812572/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.812572/full

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