Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast

Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast

Aneuploidy and epigenetic alterations have long been associated with carcinogenesis, but it was unknown whether aneuploidy could disrupt the epigenetic states required for cellular differentiation. In this study, we found that ~3% of random aneuploid karyotypes in yeast disrupt the stable inheritanc...

Full description

Bibliographic Details
Main Authors: Wahid A Mulla, Chris W Seidel, Jin Zhu, Hung-Ji Tsai, Sarah E Smith, Pushpendra Singh, William D Bradford, Scott McCroskey, Anjali R Nelliat, Juliana Conkright, Allison Peak, Kathryn E Malanowski, Anoja G Perera, Rong Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
aneuploidy
epigenetic instability
chromatin silencing
cellular differentiation
Online Access:https://elifesciences.org/articles/27991

Internet

https://elifesciences.org/articles/27991

Similar Items