A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation

A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation

Abstract Background Patients with relapsed and refractory solid and central nervous system (CNS) tumors have poor outcomes and need novel therapeutic options. Vincristine, irinotecan, and temozolomide (VIT) is a common chemotherapy regimen in relapsed pediatric tumors with an established toxicity pr...

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Bibliographic Details
Main Authors: Jonathan L. Metts, Matteo Trucco, Daniel A. Weiser, Patrick Thompson, Eric Sandler, Tiffany Smith, Jessica Crimella, Samer Sansil, Ram Thapa, Brooke L. Fridley, Nicholas Llosa, Thomas Badgett, Richard Gorlick, Damon Reed, Jonathan Gill
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Cancer Medicine
Subjects:
irinotecan
metformin
pediatric
phase I
temozolomide
vincristine
Online Access:https://doi.org/10.1002/cam4.5297

Internet

https://doi.org/10.1002/cam4.5297

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