Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

Abstract The Hydroxycarboxylic acid receptor 2 (HCA2), also known as the niacin receptor or GPR109A, is a prototypical GPCR that plays a central role in the inhibition of lipolytic and atherogenic activities. Its activation also results in vasodilation that is linked to the side-effect of flushing a...

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Main Authors: Manish K. Yadav, Parishmita Sarma, Jagannath Maharana, Manisankar Ganguly, Sudha Mishra, Nashrah Zaidi, Annu Dalal, Vinay Singh, Sayantan Saha, Gargi Mahajan, Saloni Sharma, Mohamed Chami, Ramanuj Banerjee, Arun K. Shukla
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46239-2

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https://doi.org/10.1038/s41467-024-46239-2

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