Mapping brain networks in MPS I mice and their restoration following gene therapy

Abstract Mucopolysaccharidosis type I (MPS I) is an inherited lysosomal disorder that causes syndromes characterized by physiological dysfunction in many organs and tissues. Despite the recognizable morphological and behavioral deficits associated with MPS I, neither the underlying alterations in fu...

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Bibliographic Details
Main Authors: Wei Zhu, Li Ou, Lin Zhang, Isaac H. Clark, Ying Zhang, Xiao-Hong Zhu, Chester B. Whitley, Perry B. Hackett, Walter C. Low, Wei Chen
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39939-0