Leucine-rich repeat kinase-2 deficiency protected against cardiac remodelling in mice via regulating autophagy formation and degradation

Leucine-rich repeat kinase-2 deficiency protected against cardiac remodelling in mice via regulating autophagy formation and degradation

Introduction: Leucine-rich repetitive kinase-2 (LRRK2) is a Parkinson's disease-related gene that also participates in many inflammatory diseases. However, the functional role of LRRK2 in cardiovascular disease is not clear. Objective: In this study, we aimed to elucidate the role of LRRK2 in c...

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Bibliographic Details
Main Authors: Yuan Liu, Congqing Hao, Wei Zhang, Yuzhou Liu, Sen Guo, Ran Li, Meng Peng, Yawei Xu, Xiaoxin Pei, Haibo Yang, Yintao Zhao
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Journal of Advanced Research
Subjects:
Leucine-rich repeat kinase-2
Cardiac remodelling
Autophagy
Bcl-2
Beclin1
Rab7
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123221001387

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http://www.sciencedirect.com/science/article/pii/S2090123221001387

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