HDGF promotes gefitinib resistance by activating the PI3K/AKT and MEK/ERK signaling pathways in non-small cell lung cancer

HDGF promotes gefitinib resistance by activating the PI3K/AKT and MEK/ERK signaling pathways in non-small cell lung cancer

Abstract Hepatoma-derived growth factor (HDGF) expression is associated with poor prognosis in non-small cell lung cancer (NSCLC); however, whether HDGF affects gefitinib resistance in NSCLC remains unknown. This study aimed to explore the role of HDGF in gefitinib resistance in NSCLC and to discove...

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Bibliographic Details
Main Authors: Shuyan Han, Zhihua Tian, Huifang Tian, Haibo Han, Jun Zhao, Yanna Jiao, Chunli Wang, Huifeng Hao, Shan Wang, Jialei Fu, Dong Xue, Hong Sun, Pingping Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01476-0

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https://doi.org/10.1038/s41420-023-01476-0

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