To What Extent Do Fluorophores Bias the Biological Activity of Peptides? A Practical Approach Using Membrane-Active Peptides as Models

To What Extent Do Fluorophores Bias the Biological Activity of Peptides? A Practical Approach Using Membrane-Active Peptides as Models

The characterization of biologically active peptides relies heavily on the study of their efficacy, toxicity, mechanism of action, cellular uptake, or intracellular location, using both in vitro and in vivo studies. These studies frequently depend on the use of fluorescence-based techniques. Since m...

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Bibliographic Details
Main Authors: Marco Cavaco, Clara Pérez-Peinado, Javier Valle, Rúben D. M. Silva, João D. G. Correia, David Andreu, Miguel A. R. B. Castanho, Vera Neves
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
anticancer peptides
BBB peptide shuttles
fluorescence
fluorophore
labeling
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.552035/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.552035/full

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