Unveiling the Broad Substrate Specificity of Deoxynivalenol Oxidation Enzyme DepA and Its Role in Detoxifying Trichothecene Mycotoxins

Unveiling the Broad Substrate Specificity of Deoxynivalenol Oxidation Enzyme DepA and Its Role in Detoxifying Trichothecene Mycotoxins

DepA, a pyrroloquinoline quinone (PQQ)-dependent enzyme isolated from <i>Devosia</i> mutans 17-2-E-8, exhibits versatility in oxidizing deoxynivalenol (DON) and its derivatives. This study explored DepA’s substrate specificity and enzyme kinetics, focusing on DON and 15-acetyl-DON. Besid...

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Bibliographic Details
Main Authors: Yan Zhu, Edicon Tze Shun Chan, Nadine Abraham, Xiu-Zhen Li, Weijun Wang, Lili Mats, Honghui Zhu, Jason Carere, Ting Zhou
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Toxins
Subjects:
DepA
mycotoxin
15-acetyl-DON
PQQ-dependent enzyme
substrate specificity
structure–activity relationship
Online Access:https://www.mdpi.com/2072-6651/16/3/136

Internet

https://www.mdpi.com/2072-6651/16/3/136

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