KRAS-specific antibody binds to KRAS protein inside colorectal adenocarcinoma cells and inhibits its localization to the plasma membrane

KRAS-specific antibody binds to KRAS protein inside colorectal adenocarcinoma cells and inhibits its localization to the plasma membrane

Colorectal cancer (CRC) is the third highest incidence cancer and a leading cause of cancer mortality worldwide. To date, chemotherapeutic treatment of advanced CRC that has metastasized has a dismayed success rate of less than 30%. Further, most (80%) sporadic CRCs are microsatellite-stable and are...

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Bibliographic Details
Main Authors: Kuen Kuen Lam, Yee Syuen Low, Michelle Lo, Michelle Wong, Choong Leong Tang, Emile Tan, Aik Yong Chok, Isaac Seow-En, Siew Heng Wong, Peh Yean Cheah
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Oncology
Subjects:
KRAS
antibody therapeutics
metastatic colorectal cancer
SOX9
ex vivo culture
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1036871/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1036871/full

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