mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

mTORC2 activates Akt, a regulator of cell growth and metabolism, however, the role of mTORC2 in adipocytes is incompletely understood. Here the authors report that a mTORC2-Akt axis specifically activates ACLY to promote lipid synthesis and histone acetylation during brown adipocyte differentiation.

Bibliographic Details
Main Authors: C. Martinez Calejman, S. Trefely, S. W. Entwisle, A. Luciano, S. M. Jung, W. Hsiao, A. Torres, C. M. Hung, H. Li, N. W. Snyder, J. Villén, K. E. Wellen, D. A. Guertin
Format: Article
Language:English
Published: Nature Portfolio 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14430-w

Internet

https://doi.org/10.1038/s41467-020-14430-w

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