Successful Targeting of the Warburg Effect in Prostate Cancer by Glucose-Conjugated 1,4-Naphthoquinones

Successful Targeting of the Warburg Effect in Prostate Cancer by Glucose-Conjugated 1,4-Naphthoquinones

Treatment of castration-resistant prostate cancer (CRPC) remains challenging due to the development of drug resistance. The Warburg effect describes the ability of cancer cells to consume larger amounts of glucose compared to normal tissues. We identified derivatives of natural 1,4-naphthoquinones t...

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Bibliographic Details
Main Authors: Sergey A. Dyshlovoy, Dmitry N. Pelageev, Jessica Hauschild, Ksenia L. Borisova, Moritz Kaune, Christoph Krisp, Simone Venz, Yurii E. Sabutskii, Ekaterina A. Khmelevskaya, Tobias Busenbender, Vladimir A. Denisenko, Natalia D. Pokhilo, Lyubov N. Atopkina, Markus Graefen, Hartmut Schlüter, Valentin A. Stonik, Carsten Bokemeyer, Victor Ph. Anufriev, Gunhild von Amsberg
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
1,4-naphthoquinones
castration-resistant prostate cancer
warburg effect
mitochondria
proteomics
Online Access:https://www.mdpi.com/2072-6694/11/11/1690

Internet

https://www.mdpi.com/2072-6694/11/11/1690

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