Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury

Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury

This study investigates the protective effect of baicalein on carbon tetrachloride (CCl<sub>4</sub>)-induced acute liver injury and the underlying molecular mechanisms. Mice were orally administrated baicalein at 25 and 100 mg/kg/day for 7 consecutive days or ferrostatin-1 (Fer-1) at 10...

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Bibliographic Details
Main Authors: Chongshan Dai, Hui Li, Yang Wang, Shusheng Tang, Tony Velkov, Jianzhong Shen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antioxidants
Subjects:
baicalein
oxidative stress
ferroptosis
acute liver injury
ALOX12 pathway
Nrf2 pathway
Online Access:https://www.mdpi.com/2076-3921/10/6/976

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https://www.mdpi.com/2076-3921/10/6/976

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