Intracellular transport routes for MHC class I and their relevance for antigen cross-presentation

Intracellular transport routes for MHC class I and their relevance for antigen cross-presentation

Cross-presentation, in which exogenous antigens are presented via MHC I complexes, is involved both in the generation of anti-infectious and anti-tumoral cytotoxic CD8+ T cells and in the maintenance of immune tolerance. While cross-presentation was described almost four decades ago and while it is...

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Bibliographic Details
Main Authors: Cézaire Aimé Adiko, Joel eBabdor, ENRIC eGUTIÉRREZ MARTÍNEZ, Pierre eGuermonprez, Loredana eSaveanu
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Immunology
Subjects:
Dendritic Cells
cross-presentation
MHC class I molecules
endosomal recycling compartment (ERC)
tubular endosomes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00335/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00335/full

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