Experimental and metabolic modeling evidence for a folate-cleaving side-activity of ketopantoate hydroxymethyltransferase (PanB)

Experimental and metabolic modeling evidence for a folate-cleaving side-activity of ketopantoate hydroxymethyltransferase (PanB)

Tetrahydrofolate (THF) and its one-carbon derivatives, collectively termed folates, are essential cofact¬ors, but are inherently unstable. While it is clear that chemical oxidation can cleave folates or damage their pterin precursors, very little is known about enzymatic damage to these molec-ules o...

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Bibliographic Details
Main Authors: Jennifer eThiaville, Océane eFrelin, Carolina eGarcía-Salinas, Ghulam eHasnain, Katherine eHarrison, Rocio eDíaz de la Garza, Nicole eHorenstein, Christopher eHenry, Andrew D Hanson, Valérie ede Crécy-Lagard
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Microbiology
Subjects:
paralogs
Acinetobacter baylyi
Side-Reaction
Folate biosynthesis
Metabolite repair
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00431/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00431/full

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