Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts

Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts

Mutations in PARK2, encoding Parkin, cause an autosomal recessive form of juvenile Parkinson Disease (JPD). The aim of the present study was to investigate the impact of PARK2 mutations on mitochondrial function and morphology in human skin fibroblasts. We analyzed cells obtained from four patients...

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Bibliographic Details
Main Authors: Maria Clara eZanellati, Valentina eMonti, Chiara eBarzaghi, Chiara eReale, Nardo eNardocci, Alberto eAlbanese, Enza Maria eValente, Daniele eGhezzi, Barbara eGaravaglia
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Genetics
Subjects:
Parkinson Disease
mitochondrial dynamics
mitochondrial membrane potential
parkin
PARK2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00078/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00078/full

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