A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes

A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes

Abstract Background People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD remain elusive, hindering the develo...

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Bibliographic Details
Main Authors: Jin-Gu Lee, Yulong Fu, Jun-yi Zhu, Pei Wen, Joyce van de Leemput, Patricio E. Ray, Zhe Han
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cell & Bioscience
Subjects:
SNARE proteins
SNARE protective pool
APOL1
Renal toxicity
Nephrocytes
Serum resistance-associated (SRA) protein
Online Access:https://doi.org/10.1186/s13578-023-01147-8

Internet

https://doi.org/10.1186/s13578-023-01147-8

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