Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3β-OH

Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3β-OH

We recently reported that a neurosteroid analogue with T-channel-blocking properties (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH), induced hypnosis in rat pups without triggering neuronal apoptosis. Furthermore, we found that the inhibition of the CaV3.1 isoform of T-channels contributes...

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Bibliographic Details
Main Authors: Tamara Timic Stamenic, Francesca M. Manzella, Stefan Maksimovic, Kathiresan Krishnan, Douglas F. Covey, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
voltage-gated calcium channels
R-type calcium channels
hypnosis
EEG
neuroactive steroids
thalamus
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.850658/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.850658/full

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