Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats

Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats

Melatonin acute treatment limits obesity of young Zücker diabetic fatty (ZDF) rats by non-shivering thermogenesis (NST). We recently showed melatonin chronically increases the oxidative status of vastus lateralis (VL) in both obese and lean adult male animals. The identification of VL skeletal muscl...

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Bibliographic Details
Main Authors: D. Salagre, M. Navarro-Alarcón, M. Villalón-Mir, B. Alcázar-Navarrete, G. Gómez-Moreno, F. Tamimi, A. Agil
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Zücker diabetic fatty rat
Obesity
Non-shivering thermogenesis
SERCA-SLN
CaMKII/AMPK/PGC1α
Mitochondrial biogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224001951

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http://www.sciencedirect.com/science/article/pii/S0753332224001951

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